立体中心
化学
环戊烷
羟醛反应
部分
醛
立体化学
全合成
内酯
对映选择合成
有机化学
催化作用
作者
Junli Ao,Cheng‐He Sun,Bolin Chen,Na Yu,Guangxin Liang
标识
DOI:10.1002/ange.202114489
摘要
Abstract Total syntheses of two Isodon diterpenes, isorosthin L and isoadenolin I, are reported. The synthetic strategy features a quick assembly of two simple building blocks through a diastereoselective intermolecular aldol reaction and a subsequent radical cyclization for efficient construction of a rather complex advanced intermediate bearing a quaternary stereocenter present in all Isodon diterpenes. Oxidative cleavage of the C−C bond in the cyclopentane enabled the conversion to a lactone moiety which is desired for the construction of the molecular skeleton through reductive coupling with an aldehyde carbonyl group.
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