光热治疗
光动力疗法
纳米棒
材料科学
二氧化钛
纳米技术
光敏剂
癌症研究
医学
化学
光化学
有机化学
冶金
作者
Haoying Ge,Jianjun Du,Saran Long,Xiang Xia,Jiazhu Zheng,Ning Xu,Qichao Yao,Jiangli Fan,Xiaojun Peng
标识
DOI:10.1002/adhm.202101449
摘要
The principle of photochemical transformation has shown significant inspiration on phototherapy of solid tumors. However, both photodynamic therapy (PDT) and photothermal therapy (PTT) can induce stress response of tumor cells, which draw the attention in recent. Herein, an asymmetric and lollipop like nanostructure consisting of gold nanorod/titanium dioxide (l-TiO2 -GNR) is developed by controlling single head growth of titanium dioxide (TiO2 ) on gold nanorods (GNR). Through the reasonable utilization of hot electrons of GNR by 808 nm light irradiation, l-TiO2 -GNR perform type I-PDT, mild PTT (48 °C), and H2 therapy which is efficient for hypoxic tumors. In particular, H2 can downregulate both triphosadenine and heat shock protein which are found to be main source of tumor stress response. l-TiO2 -GNR opens a new window for treatment of hypoxic tumor by the perfect synergy of type I-PDT, mild PTT, and H2 therapy.
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