生物
蛋白激酶B
细胞生物学
蛋白激酶A
激酶
信号转导
综合应力响应
转录因子
细胞应激反应
基因
遗传学
战斗或逃跑反应
信使核糖核酸
翻译(生物学)
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2017-06-02
卷期号:18 (8)
被引量:30
标识
DOI:10.2174/1389203718666170406124547
摘要
Tribbles homolog 3 (TRIB3) is a mammalian gene that is upregulated in response to several types of cell death-inducing cellular stress. The TRIB3 protein is a pseudokinase, a protein kinase-like scaffold with impaired catalytic activity. However, research has revealed it to be prolific at forming protein– protein interactions. By binding to and regulating the activity of several key proteins, including the protein kinase Akt and transcription factors ATF4, CHOP and NF-κB, TRIB3 is at a junction of several signaling pathways. This review begins by providing insights into the characteristic protein structure and gene expression regulation mechanisms of TRIB3. Further, the diverse reported molecular roles of TRIB3 as a regulator of cell death, stress responses, inflammation, cell differentiation, protein degradation and other processes are discussed. Special attention is devoted to the involvement of TRIB3 in the pathogenesis of cancer and type 2 diabetes, two fields where TRIB3 has generated particular interest, as well as considerable debate, from a biomedical standpoint. Throughout, emphasis is placed on results obtained from animal models with altered TRIB3 expression (Trib3 knockout or overexpression mice), in order to provide insight into the contributions of TRIB3 to physiology and disease at the organism level. Keywords: TRB3, gene regulation, cell viability, tumorigenesis, integrated stress response.
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