四分位数
医学
逻辑回归
白蛋白
内科学
线性回归
小型精神状态检查
静脉血
睡眠剥夺对认知功能的影响
认知
认知障碍
老年学
人口学
置信区间
精神科
统计
社会学
数学
疾病
作者
Zhaoxue Yin,Jinglei Wang,Y B Lyu,Jiesi Luo,Yi Zeng,Xiaoming Shi
出处
期刊:PubMed
日期:2016-10-10
卷期号:37 (10): 1323-1326
被引量:5
标识
DOI:10.3760/cma.j.issn.0254-6450.2016.10.001
摘要
Objective: To explore association between serum albumin level and cognitive performance in elderly Chinese. Methods: All the subjects aged ≥65 years in the 8 longevity areas in Chinese longitudinal health longevity survey (CLHLS) were invited to participate the biomedical indepth CLHLS study, information about subjects' demographic characteristics, lifestyle, prevalence of diseases and health status was collected through household-interview. The cognitive performance was assessed with Mini Mental State Evaluation (MMSE) scale. Health examination was conducted by medical personnel and fasting venous blood samples were collected to detect the levels of triglycerides, total cholesterol, fasting glucose, creatine and blood albumin. MMSE score was compared and the trend was analyzed with generalized linear model. Association between albumin concentration and cognitive impairment was analyzed by logistic regression model. Results: Generalized linear model showed that adjusted MMSE score increased from 23.22 in the lowest quartile group to 25.07 in the highest quartile group (P for linear trend <0.001). Logistic regression analysis results showed that the higher albumin level was associated with the lower risk of cognitive impairment (P< 0.001), the OR decreased linearly with the increasing level of albumin (P<0.01), with the OR (95%CI) for the lower, higher and highest quartile groups was 0.64(0.45-0.91), 0.60(0.40-0.89) and 0.43(0.27-0.69), respectively, compared with the lowest quartile group. Conclusion: High level of serum albumin was associated with low risk of cognitive impairment.
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