2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside Attenuates Ischemia/Reperfusion-Induced Brain Injury in Rats by Promoting Angiogenesis

半影 医学 尼莫地平 血管生成 大脑中动脉 缺血 冲程(发动机) 川地31 药理学 神经保护 内科学 机械工程 工程类
作者
Ying Mu,Zhaohui Xu,Xuanxuan Zhou,Huinan Zhang,Qian Yang,Yunlong Zhang,Yanhua Xie,Juan Kang,Feng Li,Siwang Wang
出处
期刊:Planta Medica [Thieme Medical Publishers (Germany)]
卷期号:83 (08): 676-683 被引量:15
标识
DOI:10.1055/s-0042-120544
摘要

Cerebral ischemia can cause brain infarcts, which are difficult to recover due to poor angiogenesis. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside is a natural polyphenol, has antioxidant and anti-inflammatory activity, and can protect from ischemic neuronal injury. However, little is known about the effect of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside on brain microcirculation after stroke. This study aimed at investigating the influence of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside on brain lesions and angiogenesis after stroke. Sprague-Dawley rats were subjected to right middle cerebral artery occlusion and treated with vehicle, nimodipine, or different doses of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside daily beginning at 6 h post-middle cerebral artery occlusion for 14 days. The volume of cerebral infarcts, degree of neurological dysfunction, and level of microvessel density were determined longitudinally. The levels of vascular endothelial growth factor, angiopoietin 1, and angiopoietin receptor-2 expression in the brain lesions were characterized by immunohistochemistry and Western blot assays at 14 days post-middle cerebral artery occlusion. We found that 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside significantly promoted postoperative recovery in rats by minimizing the volume of cerebral infarcts and improving neurological dysfunction in a dose- and time-dependent manner. Additionally, 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside significantly increased the microvessel density in the brain and upregulated CD31 expression in ischemic penumbra, relative to that in the control. Finally, treatment with 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside significantly upregulated the relative levels of vascular endothelial growth factor, angiopoietin 1, and angiopoietin receptor-2 expression in the brain lesions of rats. Therefore, these data indicated that 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside treatment promoted angiogenesis and recovery from ischemia/reperfusion-induced brain injury in rats.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
钮祜禄萱完成签到 ,获得积分10
6秒前
CipherSage应助高高尔蓉采纳,获得30
7秒前
英勇孤丹完成签到 ,获得积分10
13秒前
15秒前
17秒前
高高尔蓉完成签到,获得积分10
19秒前
20秒前
24秒前
华理附院孙文博完成签到 ,获得积分10
27秒前
墨瞳完成签到,获得积分10
27秒前
一区种子选手完成签到,获得积分10
28秒前
手握灵珠常奋笔完成签到,获得积分10
28秒前
余味应助科研通管家采纳,获得10
29秒前
ding应助科研通管家采纳,获得10
30秒前
CLTTTt完成签到,获得积分10
31秒前
freeway完成签到,获得积分10
33秒前
支雨泽完成签到,获得积分10
34秒前
37秒前
37秒前
zhoutiantian完成签到 ,获得积分10
38秒前
拾叁发布了新的文献求助10
41秒前
ljm发布了新的文献求助10
41秒前
Russula_Chu应助安详的健柏采纳,获得10
45秒前
你可真下饭完成签到 ,获得积分10
46秒前
欧巴拉吧发布了新的文献求助20
46秒前
Wang完成签到,获得积分10
49秒前
zhixian完成签到,获得积分10
50秒前
ylky完成签到 ,获得积分10
52秒前
tiankong完成签到,获得积分10
56秒前
cata完成签到,获得积分10
58秒前
胡周瑜完成签到 ,获得积分10
58秒前
小伊001完成签到,获得积分10
1分钟前
五本笔记完成签到 ,获得积分10
1分钟前
千帆破浪完成签到 ,获得积分10
1分钟前
王倩的老公完成签到 ,获得积分10
1分钟前
tiantian0518完成签到 ,获得积分10
1分钟前
李健的小迷弟应助夏陌采纳,获得10
1分钟前
apocalypse完成签到 ,获得积分10
1分钟前
nancy吴完成签到 ,获得积分10
1分钟前
cdd完成签到,获得积分10
1分钟前
高分求助中
Encyclopedia of Mathematical Physics 2nd edition 888
Technologies supporting mass customization of apparel: A pilot project 600
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
Optical and electric properties of monocrystalline synthetic diamond irradiated by neutrons 320
共融服務學習指南 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3804266
求助须知:如何正确求助?哪些是违规求助? 3349064
关于积分的说明 10341339
捐赠科研通 3065204
什么是DOI,文献DOI怎么找? 1682984
邀请新用户注册赠送积分活动 808571
科研通“疑难数据库(出版商)”最低求助积分说明 764600