5.45 ADVERSE CHILDHOOD EXPERIENCES INCREASE THE RISK OF MORTALITY: A META-ANALYSIS OF RETROSPECTIVE AND PROSPECTIVE COHORT STUDIES

Early life exposure to adverse childhood experiences (ACE), ie. Neglect, abuse, witnessing of domestic violence, or trauma in childhood has been linked to alteration of the brain structure and the neurobiological stress-response systems which have consequences for health and emotional well-being. Such experiences may be early determinants of mortality.