Intensive Insulin Treatment and QT-interval

Rate-corrected QT-interval (QTc) and QT-dispersion (QTdisp) are two related electrocardiographic variables that, apart from assessing the autonomic dysfunction, can also predict cardiac death in diabetic patients. Several studies have suggested that change of QTdisp reflects the “dynamic pathological process” in a variety of cardiac diseases. Particularly, QTdisp was found to increase significantly during ischemia and to decrease after anti-ischemic treatment during acute coronary syndromes (ACS) (1). The beneficial effect of optimal metabolic control achieved by intensive insulin therapy on the outcome of diabetic patients suffering from acute myocardial infarction has already been reported (2). Nevertheless, hyperinsulinemia has also …