海绵
生物材料
热稳定性
真皮
材料科学
组织工程
再生(生物学)
生物降解
转染
背
伤口愈合
脚手架
生物化学
生物物理学
生物医学工程
化学
解剖
生物
纳米技术
细胞生物学
有机化学
酶
免疫学
医学
植物
基因
作者
Masao Tanihara,Kouichi Kajiwara,Keiko Ida,Yoshihisa Suzuki,Masanobu Kamitakahara,Shinichi Ogata
摘要
Collagens are widely used in medical applications, but animal-derived collagens have several drawbacks, such as low thermal stability, nonspecific cell attachment, and susceptibility to contamination by infectious pathogens, such as prions, which may transfect humans. We have previously reported the chemical synthesis of polypeptides consisting of a Pro-Hyp-Gly sequence and the high thermostability of their triple-helical structure. To clarify the biomaterial characteristics of the poly(Pro-Hyp-Gly) polypeptide, we assessed its biodegradability and its capability for skin regeneration. Eight weeks after implantation, a poly(Pro-Hyp-Gly) freeze-dried sponge embedded subcutaneously into a rat dorsal area degraded at the same rate as Terudermis, which is made from bovine type I atelocollagen and is used as an artificial dermis. Surprisingly, compared with Terudermis, the poly(Pro-Hyp-Gly) sponge significantly promoted epithelialization of a full-thickness wound on a rabbit's ear pad. This chemically synthesized polypeptide may be useful as a scaffold for tissue engineering and tissue regeneration.
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