生物
红细胞生成
细胞病理学
精神障碍
病理
坏死
多核
凝固性坏死
巨细胞
凝血病
免疫学
骨髓
细胞学
贫血
内科学
医学
细胞生物学
遗传学
等离子体电池
作者
John R. MacMillan,Daniel M. Mulcahy,Marsha L. Landolt
标识
DOI:10.1577/1548-8667(1989)001<0255:cacawv>2.3.co;2
摘要
The 8-month cytopathologic progression of viral erythrocytic necrosis (VEN) disease in chum salmon Oncorhynchus keta is described. Single to multiple acidophilic, cytoplasmic viral inclusion bodies developed first in mature erythrocytes and then, within 1–2 months, all morphologically identifiable hemopoietic cell types contained VEN inclusions. Cytologic analysis indicated that multinucleate giant erythroblasts, ineffective erythropoiesis, and abnormal erythroid cell maturation occurred. A significant increase in blood coagulation time occurred concomitantly. This severe and chronic blood dyscrasia accounts for some of the pathophysiologic sequelae previously observed.
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