趋化性
多形核白细胞
化学
受体
细胞生物学
生物化学
生物
体外
作者
Izumi Ito,Toshio Hayashi,Kazuyoshi Yamada,Masafumi Kuzuya,Michitaka Naito,Akihisa Iguchi
出处
期刊:Life Sciences
[Elsevier]
日期:1995-05-01
卷期号:56 (25): 2247-2253
被引量:83
标识
DOI:10.1016/0024-3205(95)00214-q
摘要
Estrogen exhibits a variety of actions, including immuno-modulatory effects, in vivo and in vitro. The mechanism by which estrogen exerts its anti-inflammatory effect is not yet understood. We investigated the possible mechanisms of estradiol acting via the polymorphonuclear leukocytes (PMNs), which are important in the immune response. The agent, 17β-estradiol, but not 17α-estradiol, significantly reduced PMNs chemotaxis to FMLP in a dose-dependent manner (control vs estrogen 10−10~−6M,P < 0.05). Physiological concentrations of estradiol significantly reduced the chemotaxis of PMNs (10−10 mol). Pre-incubation with clomiphene or tamoxifen which are estrogen receptor antagonists, eliminated the inhibitory effect of 17β-estradiol on the chemotaxis of PMNs, restoring it to the control level. These observations suggest that 17β-estradiol suppressed the chemotaxis of PMNs by a receptor-dependent mechanism. In addition, the level of estradiol in human plasma, which PMNs were drawn, showed a close, inverse correlation with the PMNs chemotaxis to FMLP (r = −0.821 p < 0.001). Estrogen may modify the activity of neutrophils during the normal menstrual cycle, not only during pregnancy, and influence inflammation.
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