3,4-Methylenedioxyphenol attenuates systemic inflammation and oxidative stress in septic rats

Sepsis is one of the major causes of mortality in ICUs. Systemic inflammation and oxidative stress are involved in the pathogenesis and development of sepsis. 3,4-Methylenedioxyphenol (sesamol), one of the lignans in sesame oil, protects against endotoxin-induced oxidative stress and organ failure. However, the effects of sesamol on systemic inflammation and oxidative stress in septic rats have never been investigated.