RNA甲基化
生物
核糖核酸
基因表达
基因表达调控
转录后调控
甲基化
组蛋白
DNA甲基化
表观遗传学
表观遗传学
遗传学
基因
非编码RNA
计算生物学
细胞生物学
甲基转移酶
作者
Ye Fu,Dan Dominissini,Gideon Rechavi,Chuan He
摘要
Cellular RNAs carry diverse chemical modifications that used to be regarded as static and having minor roles in 'fine-tuning' structural and functional properties of RNAs. In this Review, we focus on reversible methylation through the most prevalent mammalian mRNA internal modification, N(6)-methyladenosine (m(6)A). Recent studies have discovered protein 'writers', 'erasers' and 'readers' of this RNA chemical mark, as well as its dynamic deposition on mRNA and other types of nuclear RNA. These findings strongly indicate dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins. This reversible RNA methylation adds a new dimension to the developing picture of post-transcriptional regulation of gene expression.
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