吲哚试验
分泌物
肠内分泌细胞
代谢物
生物
新陈代谢
色氨酸
色氨酸酶
生物化学
化学
氨基酸
内分泌系统
激素
作者
Catalin Chimerel,Edward C. Emery,David Summers,Ulrich F. Keyser,Fiona M. Gribble,Frank Reimann
出处
期刊:Cell Reports
[Elsevier]
日期:2014-11-01
卷期号:9 (4): 1202-1208
被引量:368
标识
DOI:10.1016/j.celrep.2014.10.032
摘要
It has long been speculated that metabolites, produced by gut microbiota, influence host metabolism in health and diseases. Here, we reveal that indole, a metabolite produced from the dissimilation of tryptophan, is able to modulate the secretion of glucagon-like peptide-1 (GLP-1) from immortalized and primary mouse colonic L cells. Indole increased GLP-1 release during short exposures, but it reduced secretion over longer periods. These effects were attributed to the ability of indole to affect two key molecular mechanisms in L cells. On the one hand, indole inhibited voltage-gated K(+) channels, increased the temporal width of action potentials fired by L cells, and led to enhanced Ca(2+) entry, thereby acutely stimulating GLP-1 secretion. On the other hand, indole slowed ATP production by blocking NADH dehydrogenase, thus leading to a prolonged reduction of GLP-1 secretion. Our results identify indole as a signaling molecule by which gut microbiota communicate with L cells and influence host metabolism.
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