髓系白血病
清脆的
脚手架
白血病
输送系统
癌症研究
医学
生物
免疫学
药理学
遗传学
生物医学工程
基因
作者
Tzu‐Chieh Ho,Hye Sung Kim,Yumei Chen,Yamin Li,Mark W. LaMere,Caroline Chen,Hui Wang,Jing Gong,Cal Palumbo,John M. Ashton,Hae‐Won Kim,Qiaobing Xu,Michael W. Becker,Kam W. Leong
出处
期刊：Science Advances
[American Association for the Advancement of Science]
日期：2021-05-19
卷期号：7 (21)
被引量：118
标识
DOI：10.1126/sciadv.abg3217
摘要
knockout reduced LSC colony-forming capacity and leukemic burden. Scaffold-based delivery increased the retention time of LNP-Cas9 in the bone marrow cavity. Overall, sustained local delivery of Cas9/IL1RAP sgRNA via CXCL12α-loaded LNP/MSCM-NF scaffolds provides an effective strategy for attenuating LSC growth to improve AML therapy.
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