聚乙烯亚胺
阳离子聚合
炎症
药理学
化学
败血症
癌症研究
生物化学
医学
免疫学
转染
基因
高分子化学
作者
Feng Liu,Shengqiang Shu,Dan Shao,Yongqiang Xiao,Yiling Zhong,Jie Zhou,Chai Hoon Quek,Yanbing Wang,Zhiming Hu,Heshi Liu,Yanhui Li,Huayu Tian,Kam W. Leong,Xuesi Chen
出处
期刊:Nano Letters
[American Chemical Society]
日期:2021-03-09
卷期号:21 (6): 2461-2469
被引量:39
标识
DOI:10.1021/acs.nanolett.0c04759
摘要
Circulating cell-free DNA (cfDNA) released by damaged cells causes inflammation and has been associated with the progression of sepsis. One proposed strategy to treat sepsis is to scavenge this inflammatory circulating cfDNA. Here, we develop a cfDNA-scavenging nanoparticle (NP) that consists of cationic polyethylenimine (PEI) of different molecular weight grafted to zeolitic imidazolate framework-8 (PEI-g-ZIF) in a simple one-pot process. PEI-g-ZIF NPs fabricated using PEI 1800 and PEI 25k but not PEI 600 suppressed cfDNA-induced TLR activation and subsequent nuclear factor kappa B pathway activity. PEI 1800-g-ZIF NPs showed greater inhibition of cfDNA-associated inflammation and multiple organ injury than naked PEI 1800 (lacking ZIF), and had greater therapeutic efficacy in treating sepsis. These results indicate that PEI-g-ZIF NPs acts as a “nanotrap” that improves upon naked PEI in scavenging circulating cfDNA, reducing inflammation, and reversing the progression of sepsis, thus providing a novel strategy for sepsis treatment.
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