Decatungstate as a direct hydrogen atom transfer photocatalyst for synthesis of trifluromethylthioesters from aldehydes

Trifluoromethylthiolation reactions of aldehydes are operated under mild condition at room temperature. The developed method tolerates a series of functional groups and has a broad substrate scope, using TBADT as HAT photoredox catalyst, and PhthSCF 3 as SCF 3 source to afford trifluoromethylthioesters. We have developed a versatile, mild protocol for trifluoromethylthiolation reactions of aldehydes with catalysis by a decatungstate hydrogen atom transfer photocatalyst under redox-neutral conditions. The protocol is highly selective, operationally simple, and compatible with a wide array of sensitive functional groups. It can be used for late-stage functionalization of bioactive molecules, which makes it convenient for drug discovery.