Cas9
清脆的
DNA
基因组编辑
亚基因组mRNA
计算生物学
化学
生物
基因
生物化学
作者
Wujin Sun,Wenyan Ji,Jordan M. Hall,Quanyin Hu,Chao Wang,Chase L. Beisel,Zhen Gu
标识
DOI:10.1002/anie.201508399
摘要
A biologically inspired carrier for the delivery of CRISPR–Cas9 that is based on yarn-like DNA nanoparticles, so-called DNA nanoclews, is described by Z. Gu, C. L. Beisel, and co-workers in their Communication on page 12029 ff. DNA nanoclews (the flying saucers), partially complementary to the single guide RNA (sgRNA), were efficiently loaded with Cas9/sgRNA complexes (the missiles) and delivered the complexes into human cells for genome editing. A biologically inspired carrier for the delivery of CRISPR–Cas9 that is based on yarn-like DNA nanoparticles, so-called DNA nanoclews, is described by Z. Gu, C. L. Beisel, and co-workers in their Communication on page 12029 ff. DNA nanoclews (the flying saucers), partially complementary to the single guide RNA (sgRNA), were efficiently loaded with Cas9/sgRNA complexes (the missiles) and delivered the complexes into human cells for genome editing. Propylene Epoxidation Catalysts Main Group Chemistry
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