化学
硼酸化
烯烃
对映选择合成
溶剂
组合化学
氨基甲酸酯
芳基
有机化学
催化作用
烷基
芳基
作者
Stefan Roesner,Javier Mansilla,Tim G. Elford,Ravindra P. Sonawane,Varinder K. Aggarwal
出处
期刊:Organic Letters
[American Chemical Society]
日期:2011-10-13
卷期号:13 (21): 5740-5743
被引量:91
摘要
The lithiation/borylation–protodeboronation of a homoallyl carbamate was applied to the synthesis of (+)-sertraline and (+)-indatraline. Due to the presence of the alkene, significant modifications of the methodology were required (use of 12-crown-4, TMSCl, H2O), or a solvent switch to CHCl3, to achieve high yields and high selectivities.
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