认知
激素
更年期
疾病
认知功能衰退
心理学
帕金森病
睡眠剥夺对认知功能的影响
痴呆
医学
内科学
神经科学
作者
Caroline Gurvich,Jessica Le,Natalie Thomas,Elizabeth Thomas,Jayashri Kulkarni
出处
期刊:Vitamins and hormones
日期:2021-01-01
卷期号:: 511-533
被引量:14
标识
DOI:10.1016/bs.vh.2020.12.020
摘要
Hormones of the hypothalamic-pituitary-gonadal axis that regulate reproductive function are also potent neurosteriods that have multiple effects on the development, maintenance and function of the brain. There is a growing body of evidence linking sex hormones to cognitive functioning across the lifespan. Both subjective and objective cognitive changes can occur with aging. For women, cognitive complains are commonly associated with the menopause transition-a time of significant hormone flux. Sex differences in neurodegenerative conditions associated with cognitive dysfunction, such as Alzheimer's disease and Parkinson's disease, suggest a potential link between sex hormones and cognitive decline. Evidence for the effects of hormone therapy on cognition is growing, but remains inconclusive. This chapter provides an overview of sex hormones and cognition in association with healthy aging, including a focus on the menopause transition, as well as reviewing findings linking sex hormones to cognitive decline associated with Alzheimer's disease and Parkinson's disease. An overview of hormone therapy and cognition is also provided.
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