纳米探针
光热治疗
吲哚青绿
材料科学
化学
磁共振成像
光热效应
纳米颗粒
纳米技术
医学
放射科
外科
作者
Xiaoxue Tang,Xuanqing Gong,Ao Li,Hongyu Lin,Chenyu Peng,Xianzhong Zhang,Xiaoyuan Chen,Jinhao Gao
出处
期刊:Nano Letters
[American Chemical Society]
日期:2019-12-16
卷期号:20 (1): 363-371
被引量:49
标识
DOI:10.1021/acs.nanolett.9b04016
摘要
Molecular probes featuring promising capabilities including specific targeting, high signal-to-noise ratio, and in situ visualization of deep tissues are in great demand for tumor diagnosis and therapy. 19F magnetic resonance imaging (MRI) techniques incorporating stimuli-responsive probes are anticipated to be highly beneficial for specific detection and imaging of tumors because of negligible background and deep tissue penetration. Herein, we report a cascaded multiresponsive self-assembled nanoprobe, which enables sequential redox-triggered and near-infrared (NIR) irradiation-induced 19F MR signal activation/amplification for sensing and imaging. Specifically, we designed and synthesized a cascaded multiresponsive 19F-bearing nanoprobe based on the self-assembly of amphiphilic redox-responsive 19F-containing polymers and NIR-absorbing indocyanine green (ICG) molecules. It could realize the activation of 19F signals in the reducing tumor microenvironment and subsequent signal amplification via the photothermal process. This stepwise two-stage activation/amplification of 19F signals was validated by 19F NMR and MRI both in vitro and in vivo. The multiresponsive 19F nanoprobes capable of cascaded 19F signal activation/amplification and photothermal effect exertion can provide accurate sensing and imaging of tumors.
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