Progress in developing rodent models of age-related macular degeneration (AMD)

黄斑变性 疾病 医学 生物信息学 神经科学 生物 病理 眼科
作者
Sudha Priya Soundara Pandi,J. Arjuna Ratnayaka,Andrew Lotery,Jessica L. Teeling
出处
期刊:Experimental Eye Research [Elsevier BV]
卷期号:203: 108404-108404 被引量:44
标识
DOI:10.1016/j.exer.2020.108404
摘要

Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss , typically affecting individuals from mid-life onwards. Its multifactorial aetiology and the lack of any effective treatments has spurred the development of animal models as research and drug discovery tools. Several rodent models have been developed which recapitulate key features of AMD and provide insights into its underlying pathology. These have contributed to making significant progress in understanding the disease and the identification of novel therapeutic targets. However, a major caveat with existing models is that they do not demonstrate the full disease spectrum. In this review, we outline advances in rodent AMD models from the last decade. These models feature various hallmarks associated with AMD, including oxidative stress , hypoxia , immune dysregulation , genetic mutations and environmental risk factors. The review summarises the methods by which each model was created, its pathological characteristics as well as its relation to the disease in humans. • Overview of novel experimental models of age-related macular degeneration. • Comparison of how mouse models replicate human age-related macular degeneration. • Identification of key risk factors in age-related macular degeneration development.
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