Research progress on the role of autoimmune regulator in immunological tolerance formation

Immune tolerance includes central immune tolerance and peripheral immune tolerance.The major mechanism of central tolerance is mainly due to clonal deletion of self-antigen-reactive T cells in the thymus.Peripheral tolerance mechanisms involve the deletion of peripheral mature T cells.The autoimmune regulator (Aire) plays an important role in the establishment and maintenance of central and peripheral immunological tolerance.Monoallelic mutations in Aire could cause autoimmune diseases.A large number of studies have shown that Aire may become a new target for the induction of tolerance in organ transplantation and the treatment for autoimmune diseases. Key words: Autoimmune regulator; Immunological tolerance; Negative selection; Transplant rejection reaction