The phagocyte activity of rat alveolar macrophages and their primary culture under the interaction with liposomes containing unsaturated fatty acid complex Bien has been studied in vitro. Quantitative dependence of the phagocyte number and phagocyte factor on the liposomal Bien concentration were estimated. Comparative analysis of the effects of multilayered and unilayered liposomes with Bien upon cell suspension has been carried out.