化学
溶解度
甲醇
羊毛甾醇
乙酸乙酯
色谱法
二甲基亚砜
酒
优等
有机化学
焓
非随机双液模型
乙醇
水溶液
活度系数
甾醇
胆固醇
物理
量子力学
生物化学
作者
Ke Li,Daniel Forciniti
标识
DOI:10.1021/acs.jced.9b00390
摘要
Lanosterol is a sterol derivative whose physicochemical properties are poorly understood. Pure lanosterol (>95%) was isolated from a crude product (54.6%) by a newly developed C18 reverse-phase high-performance liquid chromatography (HPLC) method. Purity and structure were confirmed by gas chromatography–mass spectrometry (GC–MS). The melting temperature and fusion enthalpy were determined to be 408.27 K and 23.61 kJ/mol, respectively. The solubility of lanosterol was measured in methanol, ethanol, isopropanol, n-propanol, acetonitrile, acetone, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), ethyl acetate, water, water–methanol, water–isopropanol, and water–ethanol binary systems using a static equilibrium setup from 277.09 to 338.78 K. The solid phases were characterized by X-ray diffraction and by scanning differential calorimetry. The solubility of lanosterol increases with an increase in temperature. The mole fraction of lanosterol in organic solvents has a minimum of 3.0 × 10–5 in methanol at 277.78 K and a maximum of 0.0048 in n-propanol at 318.93 K. The solubilities of lanosterol in organic solvents were correlated by the modified Apelblat equation and by the Wilson, NRTL, and UNIQUAC models. Furthermore, the binary water–alcohol systems were correlated by the Apelblat–Jouyban–Acree and the van’t Hoff–Jouyban–Acree models.
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