生物
结直肠癌
疾病
癌症
临床试验
肿瘤微环境
生物信息学
计算生物学
免疫学
内科学
医学
遗传学
作者
Tamsin R M Lannagan,Rene Jackstadt,Simon J. Leedham,Owen J. Sansom
标识
DOI:10.1016/j.gde.2020.12.003
摘要
Modelling human colon cancer has long been the ambition of researchers and oncologists with the aim to better replicate disease progression and treatment response. Advances in our understanding of genetics, stem cell biology, tumour microenvironment and immunology have prepared the groundwork for recent major advances. In the last two years the field has seen the progression of: using patient derived organoids (alone and in co-culture) as predictors of treatment response; molecular stratification of tumours that predict outcome and treatment response; mouse models of metastatic disease; and transplant models that can be used to de-risk clinical trials. We will discuss these advances in this review.
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