Recent progress of monogenic diabetes

Monogenic diabetes accounts for 1%-4% in pediatric diabetes. However, the majority of monogenic diabetes is often misdiagnosed as type 1 or type 2 diabetes mellitus. Currently, more than 40 related genes have been found widely covering different aspects of pancreas development, differentiation, normal morphology and function through complex transcription factor regulating network and so on. Monogenic diabetes can be precisely diagnosed by genetic tests which may potentially provide evidence for personalized therapy and genetic counseling. Key words: Monogenic diabetes; Genemutation; Molecular genetics; Pharmacogenetics