Effects of isoflurane on echocardiographic parameters of FVB/N mice and C57BL/6 mice

Objective To evaluate effects of isoflurane on echocardiographic parameters of FVB/N mice and C57BL/6 mice. Methods VisualSonics Vevo 770 Imaging System was used to obtain echocardiographic parameters of male FVB/N and C57BL/6 mice.Effects of isoflurane on cardiac contractive function and structure in two strains of mice were compared. Results FVB/N mice maintained normal cardiac contractile function and cardiac structural parameters under 1% and 2% isoflurane anesthesia.But FVB/N mice could not be well anesthetized and it was hard to capture a clear and stable image under 1% isoflurane anesthesia.C57BL/6 mice maintained a good contractile function under 1% isoflurane anesthesia.But the contractile function of C57BL/6 mice was obviously inhibited under 2% isoflurane anesthesia. Conclusions 2% isoflurane could be used in FVB/N mice.1% isoflurane could be used in C57BL/6 mice. Key words: Echocardiography; Isoflurane; FVB/N mice; C57BL/6 mice