抗生素耐药性
抗生素
细菌
生物
水平基因转移
抗菌剂
抗药性
遗传学
微生物遗传学
突变
微生物学
生物技术
基因
基因组
突变
作者
Emina Aruković,Dina Fetahović,Belma Pehlivanović
出处
期刊:IFMBE proceedings
日期:2019-05-11
卷期号:: 617-621
被引量:3
标识
DOI:10.1007/978-3-030-17971-7_93
摘要
Antibiotic resistance is a live issue when it comes to public health and emerging infectious diseases. Opinion of many experts in this field is that misuse or overuse of antibiotics have contributed to fast development of antibiotic resistance. This paper is focused on genetics alterations of bacteria caused by misuse of antibiotics. The acquisition of resistance can occur by horizontal or vertical transmission, so we described the mechanisms of resistance, as well as evolution of resistance genes. We explained mutagenesis induced by antibiotics, as well as recombination and lateral transfer mechanisms. At the end we got to multiple drug resistant bacteria, as a most urgent threat to a public health. Many strains of bacteria become resistant, or in many cases multi-resistant to many therapeutic drugs because of their ability to adapt to the environment and to develop different mechanisms of resistance to most old and new antimicrobial agents. Some strains have become resistant to practically all of the commonly available agents.
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