光激发
烯烃
化学
基质(水族馆)
黄素组
辅因子
反应性(心理学)
催化作用
组合化学
有机合成
酶催化
立体化学
激发态
酶
光化学
立体选择性
有机化学
核物理学
医学
替代医学
病理
地质学
物理
海洋学
作者
Kyle F. Biegasiewicz,Simon J. Cooper,Xin Gao,Daniel G. Oblinsky,Ji Hye Kim,Samuel E. Garfinkle,Leo A. Joyce,Braddock A. Sandoval,Gregory D. Scholes,Todd K. Hyster
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2019-06-21
卷期号:364 (6446): 1166-1169
被引量:264
标识
DOI:10.1126/science.aaw1143
摘要
Light teaches (co)enzymes new tricks Light is widely used in organic synthesis to excite electrons in a substrate or catalyst, opening up reactive pathways to a desired product. Biology uses light sparingly in this way, but coenzymes such as flavin can be driven to excited states by light. Biegasiewicz et al. investigated this reactivity and found a suite of flavoenzymes that catalyze asymmetric radical cyclization when exposed to light. “Ene”-reductases, when reduced and illuminated, converted starting materials containing an α-chloroamide and an alkene into five-, six-, seven-, or eight-membered lactams. Different enzymes furnished different stereochemistry in the products, likely because of changes in active-site pocket geometry. Science , this issue p. 1166
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