梅尔法兰
双膦酸盐
化学
结合
体外
部分
药理学
癌症研究
生物化学
内科学
立体化学
骨质疏松症
多发性骨髓瘤
医学
数学
数学分析
作者
Qinglin Jiang,Yang Li,Li Hai,Yong Wu
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2008-04-01
卷期号:5 (3): 229-233
被引量:6
标识
DOI:10.2174/157017808783955862
摘要
To develop a methodology for bone-specific delivery of drugs, a bone-targeting gem-bisphosphonate was used as a carrier of drugs. We had synthesized five compounds, which were a new class of potential bone-targeting reagents for bone tumors consisting of melphalan linked to a gem-bisphosphonate moiety through an amide linkage. The conjugates showed a high affinity to hydroxyapatite in vitro. Keywords: Bone-targeting, gem-bisphosphonates, melphalan, bone tumors
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