潘尼斯电池
抗菌肽
抗菌剂
生物
微生物学
微生物群
β防御素
碎片(计算)
体内
防御素
蛋白酵素
细胞生物学
生物化学
酶
遗传学
小肠
生态学
作者
Dirk Ehmann,Judith Wendler,Louis Koeninger,Ida Larsen,Thomas Klag,Jürgen Berger,André Marette,Martin Schaller,Eduard F. Stange,Nisar P. Malek,Benjamin Anderschou Holbech Jensen,Jan Wehkamp
标识
DOI:10.1073/pnas.1817376116
摘要
Significance Paneth cells provide intestinal host defense against pathogens and control the healthy microbiota by secreting antimicrobial peptides. We show that the most abundant secreted Paneth cell products, human defensin HD-5 and HD-6, show a distinct susceptibility to proteolytic digestion by human duodenal fluid. While HD-5 is digested in many fragments, HD-6 is stable and still able to form nanonets. The occurring fragments of HD-5 were antimicrobially active against microorganisms. We provide proof of concept about microbiome modulating capacities in vivo, which includes an increase of Akkermansia sp. Our results indicate that fragmentation of defensins increases antimicrobial diversity and further adds to the complexity of host microbial interaction at interfaces. Fragmentation could lead to new antimicrobial peptides with possible therapeutic usage.
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