PrefaceJulio A. Panza and Richard O. CannonContributorsPart I: The Endothelium and the Biology of Nitric OxideChapter 1: Discovery of Endothelium-Derived Relaxing Factor and Its Identification as Nitric OxideRobert F. FurchgottChapter 2: Discovery of Biological Roles of Nitric Oxide in the Cardiovascular SystemSalvador Moncada and E. Annie HiggsChapter 3: Molecular Mechanisms of Intracellular Endothelium Nitric Oxide RegulationWilliam E. Downey and Thomas MichelChapter 4: Cardiovascular Effects of Nitric Oxide: Lessons Learned from Endothelial Nitric Oxide Synthase Knockout MicePaul L. Huang, Robert Gyurko, and Lin ZhangChapter 5: Nitric Oxide Signaling Mediating Relaxation of Vascular Smooth MuscleRichard A. CohenChapter 6: Hemoglobin-Bound Nitric Oxide Participates in the Mammalian Respiratory CycleTimothy J. McMahon and Jonathan S. StamlerChapter 7: Hormonal Regulation of Endothelium-Derived Factors Virginia M. MillerPart II: Basic Mechanisms of Endothelial DysfunctionChapter 8: Endothelial Dysfunction and Vascular Disease Paul M. VanhoutteChapter 9: Endothelium-Derived Constricting Factors and Endothelial Dysfunction Frank T. Ruschitzka, Georg Noll, and Thomas F. LuscherChapter 10: Endothelial Nitric Oxide and Vascular Inflammation James K. LiaoChapter 11: Vascular Oxidant Stress and Nitric Oxide Bioactivity A. Maziar Zafari, David G. Harrison, and Kathy K. GriendlingPart III: Clinical Studies of Endothelial Function and DysfunctionChapter 12: Endothelium, Nitric Oxide, and Hypertension Julio A. PanzaChapter 13: Nitric Oxide Availability in Hypercholesterolemia Robert A. VogelChapter 14: Nitric Oxide Activity in the Human Coronary Circulation Arshed A. QuyyumiChapter 15: Endothelial Vasodilator Dysfunction in Chronic Heart Failure Helmut Drexler and Burkhard HornigChapter 16: In Vitro Studies of the Human Microcirculation in Cardiovascular Disorders Anthony M. HeagertyPart IV: Therapeutic Strategies to Improve Endothelial DysfunctionChapter 17: Endothelium as a Target of the Risk Factors in Cardiovascular Disease Scott Kinlay, Andrew P. Selwyn, and Peter GanzChapter 18: Oxidant Stress and Endothelial Function in Patients with Risk Factors for Atherosclerosis Mark A. CreagerChapter 19: Endothelium-Derived Nitric Oxide: An Antiatherogenic Molecule Shanthi Adimoolam and John P. CookeChapter 20: Hormone Therapy and Nitric Oxide Bioactivity in Postmenopausal Women Richard O. Cannon IIIChapter 21: Clinical Trials Using Angiotensin-Converting Enzyme Inhibition to Alter Endothelial Dysfunction in Coronary PatientsG. B. John ManciniChapter 22: Nitrate Therapy in Cardiovascular Disease Jonathan Abrams Index