2-Iminothiazolidin-4-ones arrest Trypanosoma cruzi growth and impair trypomastigote development in macrophages

Chagas disease, caused by the flagellate protozoan Trypanosoma cruzi, affects about 18 million people in the Americas. Current chemotherapy of Chagas disease is based on benznidazole, which is toxic and has limited efficacy. Therefore, new chemotherapeutic agents need to be developed. In this work, we describe the identification of eight Trypanosoma cruzi inhibitors through a combination of thiazoles and hydrazones chemistry.