生酮饮食
酮体
下调和上调
内分泌学
内科学
长寿
β氧化
脂肪酸代谢
新陈代谢
肥胖
生物
糖尿病
碳水化合物代谢
医学
基因
老年学
生物化学
神经科学
癫痫
作者
John C. Newman,Anthony J. Covarrubias,Minghao Zhao,Xinxing Yu,Philipp Gut,Che-Ping Ng,Yu Huang,Saptarsi M. Haldar,Eric Verdin
出处
期刊:Cell Metabolism
[Elsevier]
日期:2017-09-01
卷期号:26 (3): 547-557.e8
被引量:347
标识
DOI:10.1016/j.cmet.2017.08.004
摘要
Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies. We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction, affect longevity and healthspan in C57BL/6 male mice. We find that Cyclic KD, KD alternated weekly with the Control diet to prevent obesity, reduces midlife mortality but does not affect maximum lifespan. A non-ketogenic high-fat diet (HF) fed similarly may have an intermediate effect on mortality. Cyclic KD improves memory performance in old age, while modestly improving composite healthspan measures. Gene expression analysis identifies downregulation of insulin, protein synthesis, and fatty acid synthesis pathways as mechanisms common to KD and HF. However, upregulation of PPARα target genes is unique to KD, consistent across tissues, and preserved in old age. In all, we show that a non-obesogenic ketogenic diet improves survival, memory, and healthspan in aging mice.
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