红藻氨酸
神经保护
利多卡因
神经毒性
谷氨酸受体
药理学
兴奋毒性
促炎细胞因子
海马体
小胶质细胞
医学
神经化学
海马结构
麻醉
内分泌学
化学
内科学
炎症
毒性
受体
作者
Kuan–Ming Chiu,Cheng Wei Lu,Ming-Yi Lee,Ming Jiuh Wang,Tzu-Yu Lin,Su‐Jane Wang
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2016-05-04
卷期号:27 (7): 501-507
被引量:20
标识
DOI:10.1097/wnr.0000000000000570
摘要
Lidocaine, the most commonly used local anesthetic, inhibits glutamate release from nerve terminals. Given the involvement of glutamate neurotoxicity in the pathogenesis of various neurological disorders, this study investigated the role of lidocaine in hippocampal neuronal death and inflammatory events induced by an i.p. injection of kainic acid (KA) (15 mg/kg), a glutamate analog. The results showed that KA significantly led to neuronal death in the CA3 pyramidal layers of the hippocampus and this effect was attenuated by the systemic administration of lidocaine (0.8 or 4 mg/kg, i.p.) 30 min before KA injection. Moreover, KA-induced microglia activation and gene expression of proinflammatory cytokines, namely, interleukin-1β, interleukin-6, and tumor necrosis factor-α, in the hippocampus were reduced by the lidocaine pretreatment. Altogether, the results suggest that lidocaine can effectively treat glutamate excitotoxicity-related brain disorders.
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