D-galactose induced aging model was established by a chinese scholar named Gong Guoqing in 1991.This aging model is convenient,cheap and stable so that it has been used widespreadly comparing with other aging models such as SAMP aging model,ozone induced aging model,thymus removed model,natural aging model and so on.Reviewing the application and development of D-galactose induced aging model,and different measurements in different records,we summarized the establishment and theory of D-galactose induced aging model,furthermore,we described the measurements from ethology,biochemistry,morphology and molecular biology in this review.