Objective To study the thrombolysis of acute ischemic stroke with urokinase(UK),and to observe the clinical efficacy,looking for a safe dosage and a way fit for thrombolysis via vein Method Thrombolysis of 18 cases of acute ischemic stroke were performed with mid minidose of UK The therapy of the control group was the same as the group of thrombolysis except for not using UK Every case was scored with Europe stroke scale before and after thrombolysis and the scores were subjected to statistics to evaluat the efficacy Results The scores of ESS are higher than those before thrombolysis at the second hour,the sixth hour,the first day,the second day,the third day,the seventh day and the fourteenth day after thrombolysis The subjectives had no hemorrhage The scores of the thrombolysis group were much higher than those of control group Conclusion Compared with control group,the efficacy of thrombolysis with mid minidose is better and the side effect less [