The micromorphology study of the rat hippocampus after treated glutamate at different period

Objective In order to make clear Glutamate (Glu) having an excitotoxicity effect on neuron cells. Methods We selected the SD rats to study its response and the hippocampus micromorphology,which were treated with MSG (monosodium L glutamate,with a dose of 18 mmol/kg) subcutaneously.Results It showed that the rats were excited at the early times and were sluggish at late times.The micromorphology noted that the neurons of hippocampus showed swollen cytoplasm slightly at early times,edematous changes obviously and pyknotic nuclei of neurons at the late times,which displayed in the CA1 area range.Conclusion It suggests that the structure of hippocampus called limbic system is influenced by Glu easily and Glu has an excitotoxicity effect on neurons.It may provide basis for pharmacology and food additives.