内分泌学
内科学
色氨酸
丙二醛
脾脏
超氧化物歧化酶
化学
抗氧化剂
谷胱甘肽
谷胱甘肽过氧化物酶
腹腔注射
生理盐水
生物
生物化学
酶
医学
氨基酸
出处
期刊:Science and Technology of Food Industry
日期:2013-01-01
摘要
In order to study the effect of tryptophan(Trp)on antioxidant capacity and immunity in stressed mice,80 mice were randomly divided into four groups:the normal control group(NC),cytoxan group(CTX),cytoxan-low dose tryptophan group(CTX-L),and cytoxan-high dose tryptophan group(CTX-H).During the experiment,intraperitoneal injection of cytoxan(100mg/kg·bw)for 3d,then intragastric administration of saline and tryptophan(100,200mg/kg·bw)for 2 weeks.Results:Compared with NC group,the level of plasma malondialdehyde(MDA)had no change,tissue MDA level increased significantly.The activity of superoxide dismutase(SOD)in plasma and tissues remarkably decreased,glutathione peroxidase(GSH-Px)content and thymus index lowered in CTX group,however,Spleen Index increased.The levels of interferon-γ(IFN-γ),and interleukin-6(IL-6)decreased to different extent.5-hydroxytryptamine(5-HT)of hypothalamus decreased significantly.Compared with CTX group,in CTX-L group,the amount of MDA in tissues descended significantly.And the activity of plasma SOD recovered partly in both CTX-L and CTX-H groups,however,both groups had no effect on tissue SOD.Plasma GSH-Px increased significantly in both CTX-L and CTX-H groups,spleen GSH-Px had no significantly,however,cardiac muscle decreased significantly.The content of IFN-γ,IL-6 all enhanced significantly in CTX-H group.The content of 5-HT in hypothalamus in stressed mice was promoted significantly both in CTX-L and CTX-H groups.Conclusion:The results indicated that supplement of tryptophan involves increase of antioxidant capacity of stressed mice,and enhancement of the body's immunity.
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