Preparation and characterization of oxidized dextran

Objective To prepare the oxidized dextran.Methods The oxidized dextran has been prepared by the oxidation of dextran40 using the Sodium periodate as the oxidizing agent under the suitable conditions.The main physical properties of the resultant were characterized by the infrared spectrophotometry,ultraviolet spectrophotometry and optical rotation method.The aldehyde content of the the oxidized dextran was measured by the method of hydroxylamine hydrochloride.The molecular weight was determined by GPC.Results The.aldehyde content of oxidized dextran was 131.68%; the weight average molecular weight was 4 106; the maximum ultraviolet absorption wavelength was at 238 nm; and the specific rotation was 181.Conclusion The oxidized dextan prepared by the method mentioned above,has accurate quality control index,and it can be used as the pharmaceutic adjuvant to prepare the sustained release preparation.