The effect of catechin in different formnlation and by various administration on serum lipid level in hyperlipidemic mice was conducted. Results shows Catechin in microcapsule formulation could significantly decrease TG, TC, LDL-C level and increase HDL-C level in hyperlipidemic mice. The effect of microcapsule types Catechin is better than free Catechin and i.v. administration is better than o.p.(P0.05).