The chemical constituents and their biological activities of the Psychotria sp.were studied.Four polyphenolic compounds were isolated from the Psychotria sp.collected from Guangdong Qingpin TCM center.Their structures were determined as 11-O-syringylbergenin(1),(2 R,3 S,4S,4a R,10b S)(-)-bergenin(2),gallic acid(3),methyl gallate(4) mainly by spectroscopic analysis.All of these compounds are firstly obtained in genus of Psychotria.