Objective To explore the clinical effect of individualized cranioplasty of computer-assisted design in repairing skull defects.Methods Form Apr.2008 to Apr.2011,76 patients with skull defect were analyzed retrospectively,ultrathin cranial CT scan was performed before operation,the templates of skull defect were made under computer assistance.After patient's consent,the skull defect patches were manufactured with titanium-networks and were implanted by the operation.Results 76 patients were treated with skull repairing,the average operation duration was 65 minutes,among them,6 patients underwent ventriculo-peritoneal shunt before skull repairing.Postoperative complications were as follows: collection of fluid under the scalp was found in 6 cases,secondary bleeding in 3 cases,incision infection in 2 cases.Conclusion Individualized cranioplasty of computer-assisted design in repairing skull defects can restore patient's configuration,shorten the operation time,make operation easily,and had clinical spread value.