The Mechanism of Action and Clinical Application of Saccharomyces boulardii in Childhood Enteritis

Diarrhea is one of the major health threats to children under five years old worldwide, and repeated intestinal inflammation can also lead to malnutrition, growth retardation and other problems. Saccharomyces boulardii is the infrequent non-pathogenic fungal probiotic used in clinical practice. Compared with traditional probiotics, it has the unique advantages of antibiotic resistance, acid resistance and heat resistance, and can reach the intestine smoothly to exert its effects. This paper sorts out the multidimensional action mechanisms of Saccharomyces boulardii, including antagonizing pathogens in the intestine, regulating body nutrition and immunity, and reducing intestinal mucosal inflammation. Meanwhile, the clinical application effects of this probiotic in children with acute infectious diarrhea, antibiotic-associated diarrhea (ADD) and chronic diarrhea were introduced, and the clinical safety and potential risks of this probiotic were analyzed. Saccharomyces boulardii can effectively shorten the course of diarrhea, reduce the frequency of bowel movements, and is well tolerated. Adverse reactions may occur only in specific populations, and the risk is extremely low. With the development of precision medicine, the application prospects of Saccharomyces boulardii in children's gut health management will be even broader. This article aims to provide a basic reference for research on the restoration of the gut microbiota ecosystem in children.