化学
胺化
药效团
组合化学
催化作用
部分
乌尔曼反应
有机化学
药物发现
立体化学
生物化学
作者
Behnoush Seifinoferest,Arezoo Tanbakouchian,Bagher Larijani,Mohammad Mahdavi
标识
DOI:10.1002/ajoc.202100072
摘要
Abstract The Carbon‐Nitrogen bond formation has always been an important and useful tool in drug discovery. Its wide applications in synthesizing N‐heterocycles, known as the most prevalent moiety in the active pharmacophores, have attracted increasing attention from researchers. In recent years many works were devoted to finding new and more rapid and effective chemo‐ and regio‐selective methods for the synthesis of N‐containing heterocycles. Buchwald‐Hartwig and Ullman‐Goldberg are two proven efficient methods for synthesizing five, six, and seven‐membered heterocycles found abundantly in literature. Here, we study these two amination methods more precisely, based on the reaction conditions and the products.
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