肠道菌群
肠道微生物群
小桶
生物
属
微生物群
动物
遗传学
生物化学
基因
基因本体论
基因表达
作者
Wenyan Xian,Shumei Yang,Yu Deng,Yuzhe Yang,Chunlian Chen,Wu Li,Ruili Yang
标识
DOI:10.1021/acs.jafc.1c04849
摘要
This is the first study to report the distribution of urolithin metabotypes (UMs) in Asian people, specifically in the Chinese. As was reported for Europeans and Latin Americans, three UMs were observed, UM-A (54.3%), UM-B (31.4%), and UM-0 (14.3%), in 35 healthy Chinese youth. The richness and diversity of gut microbiota were lower in UM-0 than in UM-A and UM-B at the genus level. Gordonibacter in UM-A and UM-B was significantly higher than that in UM-0. The Akkermansia was not found in UM-0. The correlation analysis between the type and content of urolithins and the gut microbiota at the genus level showed that 27 genera were significantly positively correlated with urolithin A and 20 genera were significantly positively associated with isourolithin A and urolithin B. In addition, different KEGG pathways such as TCA cycle, energy metabolism, and some disease were found between the gut microbiome of the three UMs. Further research is needed to explore the mechanisms of metabotypes and the differential health benefits or illness predisposition of the three UMs.
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