烟曲霉
白色念珠菌
抗真菌
钴
微生物学
化学
真菌病原
立体化学
生物
有机化学
病菌
作者
Laura Ghandhi,Stefan Bidula,Christopher M. Pask,Rianne M. Lord,Patrick C. McGowan
出处
期刊:ChemMedChem
[Wiley]
日期:2021-07-29
卷期号:16 (20): 3210-3221
被引量:3
标识
DOI:10.1002/cmdc.202100159
摘要
Abstract This report highlights the synthesis and characterization of ten new bis( N ‐picolinamido)cobalt(II) complexes of the type [(L) 2 CoX 2 ] 0/2+ , whereby L= N ‐picolinamide ligand and X=diisothiocyanato (−NCS), dichlorido (−Cl) or diaqua (−OH 2 ) ligands. Single crystal X‐ray (SC‐XRD) analysis for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X‐ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus , with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.
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