微囊藻毒素
蓝藻
生物
水华
藻类
生物合成
光合作用
生态学
生物化学
浮游植物
遗传学
细菌
营养物
酶
作者
Chen Zhou,Hui Chen,Haipeng Zhao,Qiang Wang
标识
DOI:10.1016/j.algal.2021.102277
摘要
Population growth and its associated pressure on agricultural, urban, and industrial development have increased the incidence of harmful algal blooms. Microcystins are toxins produced by a variety of bloom-forming cyanobacteria that can cause hepatotoxicity in humans and animals. In this review article, we summarize progress in the understanding of microcystin biosynthesis and the effects of this toxin on surrounding organisms. We also present possible directions for further understanding the basic biology of microcystin biosynthesis. In particular, heterologous synthesis of microcystins in model cyanobacteria based on photosynthesis through the synthetic biology techniques will be an important step towards clarifying how microcystins are produced, how their synthesis is regulated, and how toxicity is produced in neighboring photosynthetic algae. The information presented here serves as a reference both for algal researchers and policymakers involved in setting future directions in microalgal research, particularly pertaining to microalgal-based microcystin biosynthesis.
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