Encapsulation of High Biocompatible Hydrophobe Contents in Nonionic Nanoparticles by Miniemulsion Polymerization of Vinyl Acetate or Styrene: Influence of the Hydrophobe Component on the Polymerization

Abstract Summary: Encapsulation of hydrophobic compounds in non ionic nanoparticles can easily be performed directly by miniemulsion polymerization of vinyl acetate or styrene with Pluronic F68 as nonionic surfactant and AIBN as initiator. Triglycerides from fatty acid (Miglyol®) or mixture of benzyl benzoate and oligocaprolactones have been used as the hydrophobe component in order to get biocompatible systems. Latexes containing 50% organic phase have been obtained with up to 50% Mygliol engulfed in the nanoparticles. The influence of these hydrophobic compounds on kinetics and molecular weight distribution has been investigated, emphasizing a particular behavior with each one of the two different monomers and compared with the classical hexadecane. magnified image