Novel Therapeutic Drug Target Discoveries for Alcohol Use Disorder and Problem Drinking: A Multi-Level Proteome-Wide Mendelian Randomization Study

Alcohol use disorder (AUD) is a common neuropsychiatric disorder that is a leading cause of morbidity and mortality worldwide; however, only a few pharmacological treatment options are currently available. While protein biomarkers with causal genetic evidence are promising novel drug target candidates for AUD, systematic scans of brain proteins have not been performed.